Carvedilol prevents impairment of the counterregulatory response in recurrently hypoglycaemic diabetic rats.

ABSTRACT:

Aim

It has been suggested that repeated activation of the adrenergic system during antecedent episodes of hypoglycaemia contributes to the development of counterregulatory failure. We previously reported that treatment with carvedilol, a non-specific β-blocker, prevented the development of counterregulatory failure and improved hypoglycaemia awareness in recurrently hypoglycaemic non-diabetic rats. The current study investigated whether carvedilol has similar benefits in diabetic rats.

Methods

Recurrently hypoglycaemic streptozotocin-diabetic rats (STZ+RH) were treated with carvedilol for one week prior to undergoing a hypoglycaemic clamp. Hypoglycaemia awareness was evaluated in streptozotocin-diabetic rats made hypoglycaemia unaware using repeated injections of 2-deoxygluc

SUBMITTER: Farhat R 

PROVIDER: S-EPMC8029566 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature