Mortality and Paclitaxel-Coated Devices: An Individual Patient Data Meta-Analysis.

ABSTRACT:

Background

Paclitaxel-containing devices (PTXDs) significantly reduce reintervention in patients with symptomatic femoropopliteal peripheral artery disease. A recent aggregate-data meta-analysis reported increased late mortality in patients with peripheral artery disease treated with PTXDs. We performed an individual patient data meta-analysis to evaluate mortality.

Methods

Manufacturers of US Food and Drug Administration-approved and commercially available devices in the United States provided deidentified individual patient data for independent analysis. Cox proportional hazards 1-stage meta-analysis models using intention-to-treat methods were used for the primary analysis. A secondary analysis of recovered missing vital status data was performed. The impact of control cr

SUBMITTER: Rocha-Singh KJ 

PROVIDER: S-EPMC8029645 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature