Whole-Proteome Differential Screening Identifies Novel Vaccine Candidates for Schistosomiasis japonica.

ABSTRACT: Schistosomiasis remains a leading cause of chronic morbidity in endemic regions despite decades of widespread mass chemotherapy with praziquantel. Using our whole proteome differential screening approach, and plasma and epidemiologic data from a longitudinal cohort of individuals living in a Schistosoma japonicum-endemic region of the Philippines, we interrogated the parasite proteome to identify novel vaccine candidates for Schistosoma japonicum. We identified 16 parasite genes which encoded proteins that were recognized by immunoglobulin G or immunoglobulin E antibodies in the plasma of individuals who had developed resistance to reinfection, but were not recognized by antibodies in the plasma of individuals who remained susceptible to reinfection. Antibody levels to Sj6-8 and Sj4-1 meas

SUBMITTER: Wu HW 

PROVIDER: S-EPMC8030711 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature