Calming the inflammatory storm in severe COVID-19 infections: Role of biologics- A narrative review.

ABSTRACT: The risk of Coronavirus infection continues, and the fear of resurgence indicates the lack of a successful therapeutic strategy. In severe COVID-19 infection, many immune cells and their products are involved, making management difficult. The abundant release of cytokines and chemokines in severe COVID-19 patients leads to profound hyper inflammation and the mobilization of immune cells, triggering the cytokine storm. The complications associated with the cytokine storm include severe respiratory distress, intravascular coagulation, multi-organ failure, and death. The enormous formation of interleukin (IL)-6 and hemopoietic factors such as granulocyte-macrophage colony-stimulating factor (GM-CSF) are implicated in the severity of the infection. Moreover, these inflammatory cytokines and fa

SUBMITTER: Banji D 

PROVIDER: S-EPMC8030716 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature