Antibody-Dependent Natural Killer Cell Activation After Ebola Vaccination.

ABSTRACT:

Background

Antibody Fc-mediated functions, such as antibody-dependent cellular cytotoxicity, contribute to vaccine-induced protection against viral infections. Fc-mediated function of anti-Ebola glycoprotein (GP) antibodies suggest that Fc-dependent activation of effector cells, including natural killer (NK) cells, could play a role in vaccination against Ebola virus disease.

Methods

We analyzed the effect on primary human NK cell activation of anti-Ebola GP antibody in the serum of United Kingdom-based volunteers vaccinated with the novel 2-dose heterologous adenovirus type 26.ZEBOV, modified vaccinia Ankara-BN-Filo vaccine regimen.

Results

We demonstrate primary human NK cell CD107a and interferon γ expression, combined with down-regulation of CD16, in response to r

SUBMITTER: Wagstaffe HR 

PROVIDER: S-EPMC8030727 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature