Dataset Information
Early T cell and binding antibody responses are associated with COVID-19 RNA vaccine efficacy onset.
Ontology highlight
ABSTRACT: Background
RNA vaccines against coronavirus disease 2019 (COVID-19) have demonstrated ∼95% efficacy in phase III clinical trials. Although complete vaccination consisted of 2 doses, the onset of protection for both licensed RNA vaccines was observed as early as 12 days after a single dose. The adaptive immune response that coincides with this onset of protection could represent the necessary elements of immunity against COVID-19.Methods
Serological and T cell analysis was performed in a cohort of 20 healthcare workers after receiving the first dose of the Pfizer/BioNTech BNT162b2 vaccine. The primary endpoint was the adaptive immune responses detectable at days 7 and 10 after dosing.Findings
Spike-specific T cells and binding antibodies were detectable 10 days after the first dose of the vaccine, in contrast to receptor-blocking and severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) neutralizing antibodies, which were mostly undetectable at this early time point.Conclusions
Our findings suggest that early T cell and binding antibody responses, rather than either receptor-blocking or virus neutralizing activity, induced early protection against COVID-19.Funding
The study was funded by a generous donation from The Hour Glass to support COVID-19 research.
SUBMITTER: Kalimuddin S
PROVIDER: S-EPMC8030737 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Publications
Early T cell and binding antibody responses are associated with COVID-19 RNA vaccine efficacy onset.
Med (New York, N.Y.) 20210408 6
<h4>Background</h4>RNA vaccines against coronavirus disease 2019 (COVID-19) have demonstrated ∼95% efficacy in phase III clinical trials. Although complete vaccination consisted of 2 doses, the onset of protection for both licensed RNA vaccines was observed as early as 12 days after a single dose. The adaptive immune response that coincides with this onset of protection could represent the necessary elements of immunity against COVID-19.<h4>Methods</h4>Serological and T cell analysis was perform ...[more]
