HDL cholesterol levels and endothelial glycocalyx integrity in treated hypertensive patients.

ABSTRACT: Endothelial dysfunction indicates target organ damage in hypertensive patients. The integrity of endothelial glycocalyx (EG) plays a vital role in vascular permeability, inflammation and elasticity, and finally to cardiovascular disease. The authors aimed to investigate the role of increased HDL cholesterol (HDL-C) levels, which usually are considered protective against cardiovascular disease, in EG integrity in older hypertensive patients. The authors studied 120 treated hypertensive patients older than 50 years were divided regarding HDL-C tertiles in group HDL_H (HDL-C ≥ 71 mg/dL, upper HDL-C tertile) and group HDL_L (HDL-C < 71 mg/dL, two lower HDL-C tertiles). Increased perfusion boundary region (PBR) of the sublingual arterial microvessels (ranging from 5 to 9 µm)

SUBMITTER: Triantafyllidi H 

PROVIDER: S-EPMC8030954 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature