Inhibitory neurons exhibit high controlling ability in the cortical microconnectome.

ABSTRACT: The brain is a network system in which excitatory and inhibitory neurons keep activity balanced in the highly non-random connectivity pattern of the microconnectome. It is well known that the relative percentage of inhibitory neurons is much smaller than excitatory neurons in the cortex. So, in general, how inhibitory neurons can keep the balance with the surrounding excitatory neurons is an important question. There is much accumulated knowledge about this fundamental question. This study quantitatively evaluated the relatively higher functional contribution of inhibitory neurons in terms of not only properties of individual neurons, such as firing rate, but also in terms of topological mechanisms and controlling ability on other excitatory neurons. We combined simultaneous electrical rec

SUBMITTER: Kajiwara M 

PROVIDER: S-EPMC8031186 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature