Low vs standardized dose anticoagulation regimens for extracorporeal membrane oxygenation: A meta-analysis.

ABSTRACT:

Background

To compare the safety and efficacy of low-dose anticoagulation (LA) with that of standardized dose anticoagulation (SA) for patients supported with extracorporeal membrane oxygenation (ECMO).

Methods

PubMed, MEDLINE, the Cochrane Library, and Web of Science were screened for original articles. Screening was performed using predefined search terms to identify cohort studies reporting the comparison of LA with SA in patients supported with ECMO from Nov 1990 to Jun 2020. The effect size was determined by the odds ratio (OR) with the 95% confidence interval (CI).

Results

An analysis of 7 studies including a total of 553 patients was performed. LA (Low-heparin group) was administered to 255 patients, whereas the other 298 patients received SA (Full-heparin grou

SUBMITTER: Lv X 

PROVIDER: S-EPMC8031334 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature