FGF23, Frailty, and Falls in SPRINT.

ABSTRACT:

Background/objectives

Chronic kidney disease (CKD) is associated with frailty. Fibroblast growth factor 23 (FGF23) is elevated in CKD and associated with frailty among non-CKD older adults and individuals with human immunodeficiency virus. Whether FGF23 is associated with frailty and falls in CKD is unknown.

Design

Cross-sectional and longitudinal observational study.

Setting

Systolic Blood Pressure Intervention Trial (SPRINT), a randomized trial evaluating standard (systolic blood pressure [SBP] <140 mm Hg) versus intensive (SBP <120 mm Hg) blood pressure lowering on cardiovascular and cognitive outcomes among older adults without diabetes mellitus.

Participants

A total of 2,376 participants with CKD (estimated glomerular filtration rate [eGFR] <60 mL/min/1.73

SUBMITTER: Jovanovich A 

PROVIDER: S-EPMC8031468 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature