Vitamin D receptor genetic polymorphism is significantly associated with decreased risk of hypertension in a Chinese Han population.

ABSTRACT: The aim of this study was to investigate the association of vitamin D receptor (VDR) gene polymorphism and hypertension in a Chinese Han population. The authors genotyped 3 tagSNPs (rs11574129, rs2228570, and rs739837) of the VDR gene using TaqMan assays in a case-control study including 2409 patients with hypertension and 3063 controls. The results showed that rs2228570 presented statistical correlations with decreased risk of male hypertension after adjustment for confounding factors, odds ratios (ORs) and 95% confidence intervals (CIs) of additive, dominant, and recessive models were 0.828 (0.74-0.927), 0.75 (0.631-0.89), and 0.816 (0.67-0.995), and P values were .001, .001, and .044, respectively. Significant associations were found in the smoking population and ORs (95% CIs) of additi

SUBMITTER: Jia J 

PROVIDER: S-EPMC8031604 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature