Lysosomal degradation ensures accurate chromosomal segregation to prevent chromosomal instability.

ABSTRACT: Lysosomes, as primary degradative organelles, are the endpoint of different converging pathways, including macroautophagy. To date, lysosome degradative function has been mainly studied in interphase cells, while their role during mitosis remains controversial. Mitosis dictates the faithful transmission of genetic material among generations, and perturbations of mitotic division lead to chromosomal instability, a hallmark of cancer. Heretofore, correct mitotic progression relies on the orchestrated degradation of mitotic factors, which was mainly attributed to ubiquitin-triggered proteasome-dependent degradation. Here, we show that mitotic transition also relies on lysosome-dependent degradation, as impairment of lysosomes increases mitotic timing and leads to mitotic errors, thus promotin

SUBMITTER: Almacellas E 

PROVIDER: S-EPMC8032240 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature