Predictive value of sub classification of focal segmental glomerular sclerosis in Oxford classification of IgA nephropathy.

ABSTRACT:

Background

The Oxford classification of IgA nephropathy (IgAN) was revised in 2016 which lacked sufficient evidence for prognostic value of subclassification of focal segmental glomerular sclerosis (S lesion), and the proper proportion of S lesion for subclassification remains undetermined.

Aim

This study aimed to explore the predictive value of the new subclassification of S score on renal outcomes of IgAN patients.

Methods

348 patients with IgAN-associated S lesion were enrolled. According to the optimal cut-off of 25% established by receiver operating characteristic (ROC) curves, we divided S1 patients into two groups: S1a group (S lesion < 25%) and S1b group (S lesion ≥ 25%). IgAN patients with mild lesion (M0E0S0T0C0) were set as the control group. The clinical f

SUBMITTER: Yu F 

PROVIDER: S-EPMC8032344 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature