Association of Dilated Perivascular Spaces With Cognitive Decline and Incident Dementia.

ABSTRACT:

Objective

To determine whether severe perivascular space (PVS) dilation is associated with longitudinal cognitive decline and incident dementia over 4 and 8 years, respectively, we analyzed data from a prospective cohort study.

Methods

A total of 414 community-dwelling older adults aged 72-92 years were assessed at baseline and biennially for up to 8 years, with cognitive assessments, consensus dementia diagnoses, and 3T MRI. The numbers of PVS in 2 representative slices in the basal ganglia (BG) and centrum semiovale (CSO) were counted and severe PVS pathology defined as the top quartile. The effects of severe PVS pathology in either region or both regions and those with severe BG PVS and severe CSO PVS were examined. White matter hyperintensity volume, cerebral microbleed

SUBMITTER: Paradise M 

PROVIDER: S-EPMC8032377 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature