Shared Molecular Mechanisms between Alzheimer's Disease and Periodontitis Revealed by Transcriptomic Analysis.

ABSTRACT:

Objective

To investigate the genetic crosstalk mechanisms that link periodontitis and Alzheimer's disease (AD).

Background

Periodontitis, a common oral infectious disease, is associated with Alzheimer's disease (AD) and considered a putative contributory factor to its progression. However, a comprehensive investigation of potential shared genetic mechanisms between these diseases has not yet been reported.

Methods

Gene expression datasets related to periodontitis were downloaded from the Gene Expression Omnibus (GEO) database, and differential expression analysis was performed to identify differentially expressed genes (DEGs). Genes associated with AD were downloaded from the DisGeNET database. Overlapping genes among the DEGs in periodontitis and the AD-related genes

SUBMITTER: Jin J 

PROVIDER: S-EPMC8032519 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature