Association between lipid-lowering agents and severe hyponatremia: a population-based case-control study.

ABSTRACT:

Purpose

Drug-induced hyponatremia is common, with medications from many drug-classes implicated. Lipid-lowering agents are among the most prescribed drugs. Limited evidence suggests an inverse association between statins and hyponatremia, while data on other lipid-lowering agents is absent. The objective of this investigation was to study the association between lipid-lowering drugs and hospitalization due to hyponatremia.

Methods

This was a register-based case-control study of the general Swedish population. Those hospitalized with a main diagnosis of hyponatremia (n = 11,213) were compared with matched controls (n = 44,801). Multivariable logistic regression adjusting for co-medication, diseases, previous hospitalizations, and socioeconomic factors was used to explore the

SUBMITTER: Skov J 

PROVIDER: S-EPMC8032630 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature