Combustion-derived particles from biomass sources differently promote epithelial-to-mesenchymal transition on A549 cells.

ABSTRACT: Combustion-derived particles (CDPs), due to the presence in their composition of several toxic and carcinogenic chemical compounds, such as polycyclic aromatic hydrocarbons (PAHs) and metals, are linked to several respiratory diseases, including lung cancer. Epithelial-to-mesenchymal transition (EMT) is a crucial step in lung cancer progression, involving several morphological and phenotypical changes. The study aims to investigate how exposure to CDPs from different biomass sources might be involved in cancer development, focusing mainly on the effects linked to EMT and invasion on human A549 lung cells. Biomass combustion-derived particles (BCDPs) were collected from a stove fuelled with pellet, charcoal or wood, respectively. A time course and dose response evaluation on cell viability

SUBMITTER: Marchetti S 

PROVIDER: S-EPMC8032642 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature