Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon.

ABSTRACT: Intestinal microbiota-derived metabolites have biological importance for the host. Polyamines, such as putrescine and spermidine, are produced by the intestinal microbiota and regulate multiple biological processes. Increased colonic luminal polyamines promote longevity in mice. However, no direct evidence has shown that microbial polyamines are incorporated into host cells to regulate cellular responses. Here, we show that microbial polyamines reinforce colonic epithelial proliferation and regulate macrophage differentiation. Colonisation by wild-type, but not polyamine biosynthesis-deficient, Escherichia coli in germ-free mice raises intracellular polyamine levels in colonocytes, accelerating epithelial renewal. Commensal bacterium-derived putrescine increases the abundance of anti-infla

SUBMITTER: Nakamura A 

PROVIDER: S-EPMC8032791 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature