Repurposing Saquinavir for Host-Directed Therapy to Control Mycobacterium Tuberculosis Infection.

ABSTRACT: Despite the available antibiotics, tuberculosis (TB) has made its return since the 90's of the last century as a global threat mostly due to co-infection with HIV, to the emergence of drug resistant strains and the lack of an effective vaccine. Host-directed strategies could be exploited to improve treatment efficacy, contain drug-resistant strains, improve immune responses and reduce disease severity. Macrophages in the lungs are often found infected with Mycobacterium tuberculosis (Mtb) and/or with HIV. The long-term survival of lung macrophages infected with Mtb or with HIV, together with their ability to produce viral particles, especially during TB, makes these niches major contributors to the pathogenicity of the infection. Among the available drugs to control HIV infection, p

SUBMITTER: Pires D 

PROVIDER: S-EPMC8032898 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature