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The Myotendinous Junction-A Vulnerable Companion in Sports. A Narrative Review.

ABSTRACT: The incidence of strain injuries continues to be high in many popular sports, especially hamstring strain injuries in football, despite a documented important effect of eccentric exercise to prevent strains. Studies investigating the anatomical properties of these injuries in humans are sparse. The majority of strains are seen at the interface between muscle fibers and tendon: the myotendinous junction (MTJ). It has a unique morphology with a highly folded muscle membrane filled with invaginations of collagen fibrils from the tendon, establishing an increased area of force transmission between muscle and tendon. There is a very high rate of remodeling of the muscle cells approaching the MTJ, but little is known about how the tissue adapts to exercise and which structural changes heavy eccentric exercise may introduce. This review summarizes the current knowledge about the anatomy, composition and adaptability of the MTJ, and discusses reasons why strain injuries can be prevented by eccentric exercise.

SUBMITTER: Jakobsen JR

PROVIDER: S-EPMC8032995 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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The Myotendinous Junction-A Vulnerable Companion in Sports. A Narrative Review.

Jakobsen Jens Rithamer JR Krogsgaard Michael Rindom MR

Frontiers in physiology 20210326

The incidence of strain injuries continues to be high in many popular sports, especially hamstring strain injuries in football, despite a documented important effect of eccentric exercise to prevent strains. Studies investigating the anatomical properties of these injuries in humans are sparse. The majority of strains are seen at the interface between muscle fibers and tendon: the myotendinous junction (MTJ). It has a unique morphology with a highly folded muscle membrane filled with invaginatio ...[more]

PMID: 33841171

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Project description:Simple Summary Bonds with companion animals are believed to benefit human physical, psychological, and social health. Most research into the human–animal bond has focused on dogs, cats, and horses. However, many people have close relationships with other species such as fish, birds, and reptiles, yet there is limited research into human health benefits that relationships with these animals might offer. This review identified empirical studies and newspaper articles which examined health benefits from bonds with any animal species that was not cat, dog, or horse. We found studies on the health benefits of bonds with companion birds, fish, snakes, tortoises, insects, and amphibians. We also found media articles discussing the health benefits of bonds with rabbits and rats. Studies were primarily descriptive and media articles anecdotal. Nevertheless, the results suggest that non-conventional companion animal species do benefit human health. Further research is needed that examines the human–animal bond, including non-traditional companion animal species, drawing on rigorous empirical methodologies. Abstract Research investigating health benefits from household human–animal bonds has focused mostly on bonds with companion dogs, cats, and horses. Wellbeing benefits associated with other companion animal species such as birds, fish, and reptiles are described and anecdotally reported, but there is little empirical literature supporting this. The literature suggests that health benefits of companion animals are predicated on human perceptions of the animal rather than the animal’s species. Therefore, relationships with non-conventional companion animals of diverse species may benefit the health of their human guardians as do dogs, cats, and horses. This narrative review summarizes the current literature exploring perceived health benefits gained from non-conventional companion animals. Searches were conducted for published literature and grey literature up to October 2022 across PsycINFO and PubMed databases, and Newsbank media database for commercial media publications. Nineteen studies and 10 media articles were included in the review. Gaps in the literature include a lack of rigorous research to investigate the health benefits of non-conventional companion animals. Non-conventional companion animals may benefit their guardians by providing social support through acting as attachment figures, facilitating social opportunities and daily routines, fulfilling cognitive needs, and recreating restorative capacities of mindfully observing natural landscapes. Further high-quality research into the human-non-conventional companion animal bond is warranted.

Project description:The myotendinous junction is a highly interdigitated interface designed to transfer muscle-generated force to tendon. Understanding how this interface is formed and organized, as well as identifying tendon- and muscle-specific extracellular matrix (ECM), is critical for designing effective regenerative therapies to restore functionality to damaged muscle-tendon units. However, a comparative analysis of the ECM proteome across this interface has not been conducted. The goal of this study was to resolve the distribution of ECM proteins that are uniformly expressed as well as those specific to each of the muscle, tendon, and junction tissues. The soleus muscles from 5-month-old wild-type C57BL/6 mice were harvested and dissected into the central muscle (M) away from tendon, the junction between muscle and tendon (J) and the tendon (T). Tissues were processed by either homogenizing in guanidine hydrochloride or fractionating to isolate the ECM from more soluble intracellular components and then analyzed using liquid chromatography-tandem mass spectrometry. Overall, we found that both tissue processing methods generated similar ECM profiles. Many ECM were found across the muscle-tendon unit, including type I collagen and associated fibril-regulating proteins. The ECM identified exclusively in M were primarily related to the basal lamina, whereas those specific to T and J tissue included thrombospondins and other matricellular ECM. Type XXII collagen (COL22A1) was restricted to J, and we identified COL5A3 as a potential marker of the muscle-tendon interface. Immunohistochemical analysis of key proteins confirmed the restriction of some basal lamina proteins to M, tenascin-C to T, and COL22A1 to J. COL5A3, PRELP, and POSTN were visualized in the tissue surrounding the junction, suggesting that these proteins play a role in stabilizing the interface. This comparative map provides a guide for tissue-specific ECM that can facilitate the spatial visualization of M, J, and T tissues and inform musculoskeletal regenerative therapies.

Dataset Information

The Myotendinous Junction-A Vulnerable Companion in Sports. A Narrative Review.

Publications

The Myotendinous Junction-A Vulnerable Companion in Sports. A Narrative Review.

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