Estrogen Receptor 1 Gene (ESR1) rs2234693 Polymorphism and Breast Cancer Risk in Saudi Women.

ABSTRACT:

Objective

The present study aimed to determine the role of ESR1 gene rs2234693 T/C polymorphism (PvuII) in the susceptibility to breast cancer and to assess the association of this polymorphism within presence or absence of estrogen, progesterone receptors, human epidermal growth factor receptor 2 (HER2) and with premenopausal and postmenopausal age in Saudi women.

Methods

The study was a retrospective case-control study. In this study, 137 breast cancer and 98 normal breast paraffin embedded tissues were included.  DNA was extracted and ESR1 gene rs2234693 T/C polymorphism was genotyped by PCR-RFLP. Genetic association tests were performed.

Results

The results showed no significant difference in distribution of rs2234693 T/C alleles and genotypes frequencies. Odd rat

SUBMITTER: Al-Amri RJ 

PROVIDER: S-EPMC8033134 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature