Diagnostic accuracy of urinary aquaporin-1 as a biomarker for renal cell carcinoma

ABSTRACT:

Introduction:

Optimal patient selection plays a vital role in management of renal tumors with the introduction of nephron-sparing approaches and active surveillance. A reliable and accurate diagnostic biomarker will be a useful adjunct to decision-making. We studied the diagnostic accuracy of urinary aquaporin-1 (uAQP-1), an upcoming urinary biomarker, for renal cell carcinoma.

Materials and Methods:

In this prospective biomarker study, urine samples were obtained preoperatively from 36 patients with an imaged renal mass suggestive of RCC and 24 healthy age-matched controls, chosen from among voluntary kidney donors. uAQP-1 concentrations were estimated with a sensitive and specific enzyme-linked immunosorbent assay (ELISA) and normalized by estimation of urinary creatini

SUBMITTER: Cheriyan A 

PROVIDER: S-EPMC8033244 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature