Under consent: participation of people with HIV in an Ebola vaccine trial in Canada.

ABSTRACT:

Background

Little is known about volunteers from Northern research settings who participate in vaccine trials of highly infectious diseases with no approved treatments. This article explores the motivations of HIV immunocompromised study participants in Canada who volunteered in a Phase II clinical trial that evaluated the safety and immunogenicity of an Ebola vaccine candidate.

Methods

Observation at the clinical study site and semi-structured interviews employing situational and discursive analysis were conducted with clinical trial participants and staff over one year. Interviews were recorded, transcribed and analysed using critical qualitative interpretivist thematic analytical techniques. Patterns were identified, clustered and sorted to generate distinct and comprehen

SUBMITTER: David PM 

PROVIDER: S-EPMC8033276 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature