Muscle damage in response to a single bout of high intensity concentric exercise in patients with Pompe disease.

ABSTRACT:

Background

In Pompe disease, resistance exercise could be an effective treatment to delay motor function impairment, however, the acute effects of this exercise modality are unclear.

Methods

In a prospective cohort study, we compared responses to a single bout of resistance exercise by serum markers of muscle damage and quantitative muscle magnetic resonance imaging (MRI) in patients (n=12) and age- and gender-matched healthy controls (n=12). Participants performed 50 maximal effort concentric knee flexions on a dynamometer.

Results

Twenty-four hours after exercise, levels of serum creatine kinase, lactate dehydrogenase and myoglobin increased in controls. In contrast, only myoglobin level increased in patients. All elevated serum markers declined by 48 hours after ex

SUBMITTER: Vaczi M 

PROVIDER: S-EPMC8033309 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature