Mitochondrial dysfunction resulting from the down-regulation of bone morphogenetic protein 5 may cause microtia.

ABSTRACT:

Background

Bone morphogenetic protein 5 (BMP5) has been identified as one of the important risk factors for microtia; however, the link between them has yet to be clarified. In this study, we aimed to demonstrate the relationship of BMP5 with mitochondrial function and investigate the specific role of mitochondria in regulating microtia development.

Methods

BMP5 expression was measured in auricular cartilage tissues from patients with and without microtia. The effects of BMP5 knockdown on cellular function and mitochondrial function were also analyzed in vitro. Changes in genome-wide expression profiles were measured in BMP5-knockdown cells. Finally, the specific impact of BMP5 down-regulation on mitochondrial fat oxidation was analyzed in vitro.

Results

SUBMITTER: Qiu YY 

PROVIDER: S-EPMC8033356 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature