Sex-related differences in cognitive trajectories in older individuals with type 2 diabetes and overweight or obesity.

ABSTRACT:

Introduction

It is unknown whether rates of cognitive decline differ between older women and men with type 2 diabetes (T2D) and overweight or obesity.

Methods

Two to four cognitive assessments were obtained across up to 10 years from 2799 adults (mean age 68 years; 62% women) with T2D who had been enrolled in a clinical trial of weight loss intervention. Sex-related differences in means and rates of decline of cognitive scores were assessed.

Results

Women outperformed men in verbal learning and processing speed (P < 0.001), but not executive function (P = 0.22). The rates of decline over time for women and men were similar (P ≥  0.10); however women, but not men, with apolipoprotein E (APOE) ε4 alleles had steeper declines in verbal learnin

SUBMITTER: Espeland MA 

PROVIDER: S-EPMC8033410 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature