A potential role for zinc in restless legs syndrome.

ABSTRACT:

Study objectives

Evaluate serum and brain noniron metals in the pathology and genetics of restless legs syndrome (RLS).

Methods

In two independent studies (cohorts 1 and 2), in which subjects either remained on medications or tapered off medications, we analyzed serum levels of iron, calcium, magnesium, manganese, copper, and zinc both in RLS patients and controls, and assessed the prevalence of the MEIS1 and BTBD9 risk alleles previously established through genome-wide association studies. Human brain sections and a nematode genetic model were also quantified for metal levels using mass spectrometry.

Results

We found a significant enrichment for the BTBD9 risk genotype in the RLS affected group compared to control (p = 0.0252), consistent with previous literature. Se

SUBMITTER: Chen P 

PROVIDER: S-EPMC8033460 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature