Association between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer in the Chinese Han population: a case-control study.

ABSTRACT:

Objective

To explore the relationship between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer (CRC) in the Chinese Han population.

Methods

rs2274907 A>T was assessed by PCR-restriction fragment length polymorphism analysis. Plasma omentin-1 expression from 358 patients with CRC and 286 healthy controls was analyzed by enzyme-linked immunosorbent assay. CRC and control groups were divided into subgroups according to the body mass index (BMI) threshold of 25 kg/m².

Results

No significant differences were observed between CRC and control groups in terms of genotype or allele frequencies of rs2274907 A>T. Compared with individuals with BMI <25 kg/m² and the rs2274907 TT genotype, those with AA+AT genotypes and BMI ≥25 kg/m^2</

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8033482 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature