Evaluation of Shared Genetic Susceptibility to High and Low Myopia and Hyperopia.

ABSTRACT:

Importance

Uncertainty currently exists about whether the same genetic variants are associated with susceptibility to low myopia (LM) and high myopia (HM) and to myopia and hyperopia. Addressing this question is fundamental to understanding the genetics of refractive error and has clinical relevance for genotype-based prediction of children at risk for HM and for identification of new therapeutic targets.

Objective

To assess whether a common set of genetic variants are associated with susceptibility to HM, LM, and hyperopia.

Design, setting, and participants

This genetic association study assessed unrelated UK Biobank participants 40 to 69 years of age of European and Asian ancestry. Participants 40 to 69 years of age living in the United Kingdom were recruited from J

SUBMITTER: Tideman JWL 

PROVIDER: S-EPMC8033508 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature