Effect of resveratrol on mouse ovarian vitrification and transplantation.

ABSTRACT:

Background

After ovarian tissue transplantation, ischemia-reperfusion injury and free radicals cause follicle depletion and apoptosis. Therefore, the use of antioxidants to reduce the production of free radicals is an important method to address the consequences of ischemia-reperfusion injury. Resveratrol is a natural active polyphenol compound with anti-inflammatory, antitumor, strong antioxidant and anti-free radical properties. The aim of this study was to investigate whether resveratrol could improve the effect of autologous ovarian transplantation after cryopreserve-thawn mouse ovarian tissue.

Methods

Whole-ovary vitrification and autotransplantation models were used to investigate the effects of resveratrol. Six-week-old female mice from the Institute of Cancer Researc

SUBMITTER: Wang D 

PROVIDER: S-EPMC8033708 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature