A multispecies outbreak of carbapenem-resistant bacteria harboring the bla_KPC gene in a non-classical transposon element.

ABSTRACT:

Background

Klebsiella pneumoniae is the most frequent KPC-producing bacteria. The bla_KPC gene is frequently embedded in Tn4401 transposon, and less frequently in non-Tn4401 elements (NTE_KPC) variants I-III. The first case of KPC in the UC-CHRISTUS Clinical Hospital was detected in Pseudomonas aeruginosa. Soon after this event, KPC was detected in 2 additional Pseudomonas aeruginosa, 3 Escherichia coli, 3 Enterobacter cloacae, 3 Klebsiella pneumoniae, and 1 Citrobacter freundii, isolated from 6 different patients. We aimed to elucidate the possible mechanisms of genetic transfer and dissemination of the bla_KPC gene among isolates of this multispecies outbreak. A molecular epidemiology analysis of the above mentioned clinical isolates (n = 13) through

SUBMITTER: Wozniak A 

PROVIDER: S-EPMC8034096 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature