N/OFQ modulates orofacial pain induced by tooth movement through CGRP-dependent pathways.

ABSTRACT:

Background

Nociceptin/orphanin FQ (N/OFQ) has been revealed to play bidirectional roles in orofacial pain modulation. Calcitonin gene-related peptide (CGRP) is a well-known pro-nociceptive molecule that participates in the modulation of orofacial pain. We aimed to determine the effects of N/OFQ on the modulation of orofacial pain and on the release of CGRP.

Methods

Orofacial pain model was established by ligating springs between incisors and molars in rats for the simulation of tooth movement. The expression level of N/OFQ was determined and pain level was scored in response to orofacial pain. Both agonist and antagonist of N/OFQ receptor were administered to examine their effects on pain and the expression of CGRP in trigeminal ganglia (TG). Moreover, gene therapy based on

SUBMITTER: Yan X 

PROVIDER: S-EPMC8034138 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature