Efficacy and safety of sprifermin injection for knee osteoarthritis treatment: a meta-analysis.

ABSTRACT:

Objective

To perform a meta-analysis comparing the structural progression and clinical symptom outcomes as well as adverse events experienced from intra-articular injections of sprifermin compared to a placebo treatment for patients with knee osteoarthritis (KOA).

Method

We systematically searched the literature for studies that compared long-term outcomes between sprifermin and placebo injections for KOA treatment. Meta-analysis was performed with RevMan5.3 using an inverse variance approach with fixed or random effects models. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated.

Results

Eight studies were included. Overall, there was significantly less improvement of WOMAC total scores in patients receiving sprifermin, compared with the placebo (mean

SUBMITTER: Zeng N 

PROVIDER: S-EPMC8034149 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature