Rates and risk factors for amputation in people with diabetes in Japan: a historical cohort study using a nationwide claims database.

ABSTRACT:

Background

The prevalence of diabetes is rising, and diabetes develops at a younger age in East Asia. Although lower limb amputation negatively affects quality of life and increases the risk of cardiovascular events, little is known about the rates and predictors of amputation among persons with diabetes from young adults to those in the "young-old" category (50-72 y).

Methods

We analyzed data from a nationwide claims database in Japan accumulated from 2008 to 2016 involving 17,288 people with diabetes aged 18-72 y (mean age 50.2 y, HbA1c 7.2%). Amputation occurrence was determined according to information from the claims database. Cox regression model identified variables related to lower limb amputation.

Results

The mean follow-up time was 5.3 years, during which ti

SUBMITTER: Kaneko M 

PROVIDER: S-EPMC8034178 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature