Plasma Metabolomic Markers of Insulin Resistance and Diabetes and Rate of Incident Parkinson's Disease.

ABSTRACT:

Background

Although there is evidence of shared dysregulated pathways between diabetes and Parkinson's disease, epidemiologic research on an association between the two diseases has produced inconsistent results.

Objective

We aimed to assess whether known metabolomic markers of insulin resistance and diabetes are also associated with Parkinson's disease development.

Methods

We conducted a nested case-control study among Nurses' Health Study and Health Professionals Follow-up Study participants who had provided blood samples up to twenty years prior to Parkinson's diagnosis. Cases were matched to risk-set sampled controls by age, sex, fasting status, and time of blood collection. Participants provided covariate information via regularly collected cohort questionnaires.

SUBMITTER: Molsberry S 

PROVIDER: S-EPMC8034435 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature