A novel epithelial-mesenchymal transition molecular signature predicts the oncological outcomes in colorectal cancer.

ABSTRACT: Epithelial-mesenchymal transition (EMT), a biological process involving the transformation of epithelial cells into mesenchymal cells, promotes tumour initiation and metastasis. The aim of this study was to construct an EMT molecular signature for predicting colorectal cancer (CRC) prognosis and evaluate the efficacy of the model. The risk scoring system, constructed by log-rank test and multivariate Cox regression analysis according to EMT-related gene expression in CRC patients from TCGA database, demonstrated the highest correlation with prognosis compared with other parameters in CRC patients. The risk scores were significantly correlated with more lymph node metastasis, distal metastasis and advanced clinical stage of CRC. The model was further successfully validated in two independen

SUBMITTER: Shan Z 

PROVIDER: S-EPMC8034457 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature