Antibiotic use and the development of inflammatory bowel disease: a national case-control study in Sweden.

ABSTRACT:

Background

Use of antibiotics in early life has been linked with childhood inflammatory bowel disease (IBD), but data for adults are mixed, and based on smaller investigations that did not compare risk among siblings with shared genetic or environmental risk factors. We aimed to investigate the association between antibiotic therapy and IBD in a large, population-based study.

Methods

In this prospective case-control study, we identified people living in Sweden aged 16 years or older, with a diagnosis of IBD based on histology and at least one diagnosis code for IBD or its subtypes (ulcerative colitis and Crohn's disease). We identified consecutive patients with incident IBD from the ESPRESSO (Epidemiology Strengthened by histoPathology Reports in Sweden) study, cross-referen

SUBMITTER: Nguyen LH 

PROVIDER: S-EPMC8034612 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature