Therapeutic cancer vaccines for pediatric malignancies: advances, challenges, and emerging technologies.

ABSTRACT: Though outcomes for pediatric cancer patients have significantly improved over the past several decades, too many children still experience poor outcomes and survivors suffer lifelong, debilitating late effects after conventional chemotherapy, radiation, and surgical treatment. Consequently, there has been a renewed focus on developing novel targeted therapies to improve survival outcomes. Cancer vaccines are a promising type of immunotherapy that leverage the immune system to mediate targeted, tumor-specific killing through recognition of tumor antigens, thereby minimizing off-target toxicity. As such, cancer vaccines are orthogonal to conventional cancer treatments and can therefore be used alone or in combination with other therapeutic modalities to maximize efficacy. To date, cancer va

SUBMITTER: Olsen HE 

PROVIDER: S-EPMC8034661 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature