Prognostic impact of LY6K and CDCA1 expression for patients with esophageal squamous cell carcinoma.

ABSTRACT:

Aim

In the present study, we investigated the relationship between the expressions of two cancer testis antigens (CTA), LY6K (lymphocyte antigen 6 complex locus K) and CDCA1 (cell division cycle associated 1), in esophageal squamous cell carcinoma (ESCC) tumors and the long-term outcomes of patients with ESCC to clarify the clinical significance of LY6K and CDCA1 expression in ESCC tumors.

Methods

A total of 175 patients with thoracic ESCC who had undergone a thoracic esophagectomy with three-field lymphadenectomy without neoadjuvant therapy were retrospectively reviewed in this study. LY6K and CDCA1 expressions were evaluated in tumor tissues using immunohistochemical (IH) staining.

Results

Median patient age was 63 years; 159 patients (90.9%) were men. Ninety-four p

SUBMITTER: Oguma J 

PROVIDER: S-EPMC8034699 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature