Co-activation patterns across multiple tasks reveal robust anti-correlated functional networks.

ABSTRACT: Whether antagonistic brain states constitute a fundamental principle of human brain organization has been debated over the past decade. Some argue that intrinsically anti-correlated brain networks in resting-state functional connectivity are an artifact of preprocessing. Others argue that anti-correlations are biologically meaningful predictors of how the brain will respond to different stimuli. Here, we investigated the co-activation patterns across the whole brain in various tasks and test whether brain regions demonstrate anti-correlated activity similar to those observed at rest. We examined brain activity in 47 task contrasts from the Human Connectome Project (N = 680) and found robust antagonistic interactions between networks. Regions of the default network exhibited the highest deg

SUBMITTER: Li M 

PROVIDER: S-EPMC8034806 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature