A dynamic nomogram for predicting diabetic macular edema in type 2 diabetes patients based on plasma cytokines.

ABSTRACT:

Objective

This study investigated changes of plasma cytokines and aimed to build a dynamic nomogram for diabetic macular edema (DME) in type 2 diabetes mellitus (T2DM).

Methods

In a pilot cohort, plasma samples were selected from 9 T2DM patients and 9 DME patients to screen for cytokine differences. The screening cytokines were then validated by enzyme-linked immunoassay in a cohort, which contained 100 DME (DME group) and 100 T2DM patients without DME (T2DM group). A dynamic nomogram for predicting DME was developed, based on the plasma cytokines.

Results

In the pilot cohort, 11 plasma cytokines were significantly increased in the DME group. In the validation cohort, platelet-derived growth factor (PDGF)-BB, tissue inhibitors of metalloproteinase (TIMP)-1, angiopoiet

SUBMITTER: Zhang N 

PROVIDER: S-EPMC8034887 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature