Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools.

ABSTRACT: The increasing prevalence of age-related diseases and resulting healthcare insecurity and emotional burden require novel treatment approaches. Several promising strategies seek to limit nutrients and promote healthy aging. Unfortunately, the human desire to consume food means this strategy is not practical for most people but pharmacological approaches might be a viable alternative. We previously showed that myriocin, which impairs sphingolipid synthesis, increases lifespan in Saccharomyces cerevisiae by modulating signaling pathways including the target of rapamycin complex 1 (TORC1). Since TORC1 senses cellular amino acids, we analyzed amino acid pools and identified 17 that are lowered by myriocin treatment. Studying the methionine transporter, Mup1, we found that newly synthesiz

SUBMITTER: Hepowit NL 

PROVIDER: S-EPMC8034917 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature