Predicting lung adenocarcinoma prognosis with a novel risk scoring based on platelet-related gene expression.

ABSTRACT: Lung adenocarcinoma is the most common subtype of non-small cell lung cancer, and platelet receptor-related genes are related to its occurrence and progression. A new prognostic indicator based on platelet receptor-related genes was developed with multivariate COX analysis. Prognostic markers based on platelet-related risk score perform moderately in prognosis prediction. The functional annotation of this risk model in high-risk patients shows that the pathways related to cell cycle, glycolysis and platelet-derived related factors are rich. It is worth noting that somatic mutation analysis shows that TTN and MUC16 have higher mutation burdens in high-risk patients. Moreover, the differential genes of high- and low-risk groups are regulated by copy number variation and miRNA. And we provide

SUBMITTER: Zhou C 

PROVIDER: S-EPMC8034940 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature