Identification of endoscopic factors that predict poor responses to steroids in patients with gastrointestinal acute graft-versus-host disease.

ABSTRACT: Gastrointestinal acute graft-versus-host disease (aGVHD) is a life-threatening complication that requires urgent and appropriate treatment. An endoscopic examination is considered the gold-standard for the diagnosis of gastrointestinal aGVHD. However, the prognostic value of endoscopy remains controversial. This study aimed to investigate the usefulness of pre-treatment macroscopic and histopathologic findings of upper and lower endoscopy with respect to predicting steroid-resistant gastrointestinal aGVHD. This retrospective study included 44 patients with gastrointestinal aGVHD who underwent endoscopy at the time of diagnosis and received systemic steroid treatment at our hospital. We graded the macroscopic and histopathologic findings using a previously validated 4-point scale. Univariat

SUBMITTER: Morita K 

PROVIDER: S-EPMC8035068 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature