Epidemiology of and risk factors for mortality due to carbapenemase-producing organisms (CPO) in healthcare facilities.

ABSTRACT:

Background

Carbapenemase-producing organisms (CPO) have been largely responsible for the extensive spread of carbapenem resistance, and their prevalence is increasing in many parts of the world.

Aim

To evaluate clinical and molecular epidemiology and mortality associated with CPO among patients.

Methods

All CPO from clinical and long-term healthcare surveillance cultures across Scotland in 2003-2017 were reviewed retrospectively. Polymerase chain reaction was used to detect genes coding for carbapenemases. A generalized linear mixed model was used to identify risk factors for mortality.

Findings

In total, 290 individuals with CPO were identified. The overall incidence increased over time (P<0.001) from 0.02 to 1.38 per 100,000 population between 2003 and 2017.

SUBMITTER: Zhao S 

PROVIDER: S-EPMC8035079 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature