Heart donation and transplantation after circulatory determination of death: expert guidance from a Canadian consensus building process.

ABSTRACT: Controlled donation after circulatory determination of death (DCD), where death is determined after cardiac arrest, has been responsible for the largest quantitative increase in Canadian organ donation and transplants, but not for heart transplants. Innovative international advances in DCD heart transplantation include direct procurement and perfusion (DPP) and normothermic regional perfusion (NRP). After death is determined, DPP involves removal and reanimation of the arrested heart on an ex situ organ perfusion system. Normothermic regional perfusion involves surgically interrupting (ligating the aortic arch vessels) brain blood flow after death determination, followed by restarting the heart and circulation in situ using extracorporeal membrane oxygenation. The objectives of this Canadi

SUBMITTER: Shemie SD 

PROVIDER: S-EPMC8035095 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature