Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice.

ABSTRACT: The accumulation of adenosine is strongly correlated with the need for sleep and the detection of sleep pressure is antagonised by caffeine. Caffeine also affects the circadian timing system directly and independently of sleep physiology, but how caffeine mediates these effects upon the circadian clock is unclear. Here we identify an adenosine-based regulatory mechanism that allows sleep and circadian processes to interact for the optimisation of sleep/wake timing in mice. Adenosine encodes sleep history and this signal modulates circadian entrainment by light. Pharmacological and genetic approaches demonstrate that adenosine acts upon the circadian clockwork via adenosine A₁/A_2A receptor signalling through the activation of the Ca²⁺ -ERK-AP-1 and CREB/CRTC

SUBMITTER: Jagannath A 

PROVIDER: S-EPMC8035342 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature