Lower cardiac output is associated with neurodegeneration among older adults with normal cognition but not mild cognitive impairment.

ABSTRACT: Subclinical cardiac dysfunction is associated with smaller total brain volume on magnetic resonance imaging (MRI). To study whether cardiac output relates to regional measurements of grey and white matter structure, older adults (n = 326) underwent echocardiogram to quantify cardiac output (L/min) and brain MRI. Linear regressions related cardiac output to grey matter volumes measured on T₁ and white matter hyperintensities assessed on T₂-FLAIR. Voxelwise analyses related cardiac output to diffusion tensor imaging adjusting for demographic, genetic, and vascular risk factors. Follow-up models assessed a cardiac output x diagnosis interaction with stratification (normal cognition, mild cognitive impairment). Cardiac output interacted with diagnosis, such that lower car

SUBMITTER: Moore EE 

PROVIDER: S-EPMC8035362 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature