Dataset Information

Lower cardiac output is associated with neurodegeneration among older adults with normal cognition but not mild cognitive impairment.

ABSTRACT: Subclinical cardiac dysfunction is associated with smaller total brain volume on magnetic resonance imaging (MRI). To study whether cardiac output relates to regional measurements of grey and white matter structure, older adults (n = 326) underwent echocardiogram to quantify cardiac output (L/min) and brain MRI. Linear regressions related cardiac output to grey matter volumes measured on T₁ and white matter hyperintensities assessed on T₂-FLAIR. Voxelwise analyses related cardiac output to diffusion tensor imaging adjusting for demographic, genetic, and vascular risk factors. Follow-up models assessed a cardiac output x diagnosis interaction with stratification (normal cognition, mild cognitive impairment). Cardiac output interacted with diagnosis, such that lower cardiac output related to smaller total grey matter (p = 0.01), frontal lobe (p = 0.01), and occipital lobe volumes (p = 0.01) among participants with normal cognition. When excluding participants with cardiovascular disease and atrial fibrillation, associations emerged with smaller parietal lobe (p = 0.005) and hippocampal volume (p = 0.05). Subtle age-related cardiac changes may disrupt neuronal homeostasis and impact grey matter integrity prior to cognitive impairment.

SUBMITTER: Moore EE

PROVIDER: S-EPMC8035362 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Lower cardiac output is associated with neurodegeneration among older adults with normal cognition but not mild cognitive impairment.

Moore Elizabeth E EE Liu Dandan D Bown Corey W CW Kresge Hailey A HA Gupta Deepak K DK Pechman Kimberly R KR Mendes Lisa A LA Davis L Taylor LT Gifford Katherine A KA Anderson Adam W AW Wang Thomas J TJ Landman Bennett A BA Hohman Timothy J TJ Jefferson Angela L AL

Brain imaging and behavior 20201010 4

Subclinical cardiac dysfunction is associated with smaller total brain volume on magnetic resonance imaging (MRI). To study whether cardiac output relates to regional measurements of grey and white matter structure, older adults (n = 326) underwent echocardiogram to quantify cardiac output (L/min) and brain MRI. Linear regressions related cardiac output to grey matter volumes measured on T<sub>1</sub> and white matter hyperintensities assessed on T<sub>2</sub>-FLAIR. Voxelwise analyses related c ...[more]

PMID: 33040257

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Lower cardiac output is associated with neurodegeneration among older adults with normal cognition but not mild cognitive impairment.

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Lower cardiac output is associated with neurodegeneration among older adults with normal cognition but not mild cognitive impairment.

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