Type I interferon signaling limits viral vector priming of CD8⁺ T cells during initiation of vitiligo and melanoma immunotherapy.

ABSTRACT: Vitiligo is an autoimmune skin disease in which epidermal melanocytes are targeted for destruction by CD8⁺ T cells specific for melanocyte/melanoma-shared antigens. IFNγ is the central cytokine driving disease, but the role of type I IFN in vitiligo remains unclear. We investigated the functional role of type I IFN during vitiligo progression using two different mouse models: one induced with a vaccinia virus (VV) vaccine and one induced with dendritic cells to prime autoimmune T cells. Induction of vitiligo by VV in IFNaR-deficient mice led to the development of severe vitiligo compared with wild-type (WT) mice and was characterized by a significantly enhanced effector CD8⁺ T-cell response. Severe vitiligo in this model was a result of VV persistence, because exacerb

SUBMITTER: Riding RL 

PROVIDER: S-EPMC8035367 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature