Role of magnifying endoscopy with narrow-band imaging in the diagnosis of noninvasive gastric neoplasia.

ABSTRACT:

Background and aim

There are no globally approved, distinguishing criteria enabling the classification of gastric adenomas and intramucosal carcinomas for differential diagnosis of noninvasive neoplasia (NIN).

Methods

Next-generation sequencing of 50 cancer-related genes was undertaken on 68 pathologically diagnosed microdissected gastric neoplasms (25 adenomas, 27 intramucosal carcinomas, and 16 submucosal carcinomas) obtained during endoscopic submucosal dissection. Findings from magnifying endoscopy with narrow-band imaging (M-NBI) of 52 NINs (the 25 adenomas and 27 intramucosal carcinomas) were compared with these data.

Results

Among all 68 neoplasms, the most frequently mutated genes were APC (76% in adenoma, 11.1% in intramucosal carcinoma, and 0% in subm

SUBMITTER: Tanaka K 

PROVIDER: S-EPMC8035442 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature